ABSTRACT
There have been sustained global efforts to promote the uptake of COVID-19 vaccines, yet studies suggest the upsurge of vaccine resistance around the world. Considering the wide adoption of social media as crucial sources of health information, thenature of popular online debates on vaccination initiatives can significantly sway people's vaccine-related decisions. This study develops a structural equation model for the predictors of COVID-19 vaccine uptake among Nigerian social mediausers. Using an online survey of 436 respondents, the study fundamentally extends the constructs of the Health Belief Model by examining the unique roles of social media exposure, fear, and anticipated regret in the prediction of individuals' vaccination decisions. We found that perceived susceptibility to and perceived severity of vaccination risk, perceived barriers to vaccination, exposure to vaccine-critical posts on social media, fear of vaccination risk, and anticipated regret for vaccine uptake significantly predicted COVID-19 vaccine uptake. However, the perceived benefits of COVID-19 vaccine uptake and anticipated regret for inaction related to vaccination did not predict COVID-19 vaccine-related decisions. The findings accentuate why stakeholders in the public health sector should pay adequate attention to social media-related trends on public health promotion schemes, and counter any detected falsehood with credible information. © 2022 the authors.